Conditional Probability of Long-term Survival After Liver Resection for...
ImportanceWhereas conventional actuarial overall survival (OS) estimates rely exclusively on static factors determined around the time of surgery, conditional survival (CS) estimates take into account...
View ArticleDetermining Chances for Survival in Intrahepatic Cholangiocarcinoma
As a patient might ask, “Doctor, now that you have successfully removed my liver cancer, what are my chances?”
View ArticlePreoperative Antiviral Treatment and Incidence of Microvascular Invasion in...
This cohort study examines the association of preoperative antiviral treatment with the incidences of microvascular invasion and posthepatectomy early tumor recurrence in adult patients with hepatitis...
View ArticleAntiviral Therapy and Tumor Resection as Treatment for Hepatocellular Carcinoma
Optimal care for hepatitis virus–related hepatocellular carcinoma (HCC) would include eradication of tumor and elimination of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection. Accomplishing...
View ArticleNab-Paclitaxel and Gemcitabine as First-line Treatment of Advanced or...
This single-arm, 2-stage, phase 2 clinical trial assesses the safety and efficacy of intravenous gemcitabine plus nanoparticle albumin-bound–paclitaxel for treatment of adults with advanced...
View ArticleHeat-Activation Concentrates Chemotherapy in Liver Tumors
In a recent proof-of-concept, open-label phase 1 trial, ultrasound noninvasively administered from outside the body safely triggered and enhanced delivery of a heat-sensitive chemotherapy drug to...
View ArticleTenofovir vs Entecavir for Hepatocellular Carcinoma Prevention in Patients...
Current guidelines for the treatment of chronic hepatitis B (CHB) recommend as first-line line therapy entecavir (ETV), tenofovir disoproxil fumarate (TDF), or tenofovir alafenamide fumarate. Both ETV...
View ArticleRisk of Hepatocellular Carcinoma After Treatment With Entecavir vs Tenofovir...
This cohort study uses data from the Korean National Health Insurance Service database to compare the risk of hepatocellular cancer associated with entecavir vs tenofovir disoproxil fumarate in...
View ArticleMetastatic Calcinosis Cutis Associated With a Selective FGFR Inhibitor
This case report describes metastatic calcinosis cutis associated with selective FGFR inhibitor therapy.
View ArticleOutcomes of Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy
This cohort study compares outcomes of cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy for peritoneal metastasis with outcomes of similar-risk surgical oncology procedures...
View ArticleAssociation Between Noninvasive Fibrosis Markers and Mortality After Hepatectomy
This cohort study examines whether aspartate aminotransferase–platelet ratio index and fibrosis 4 values are asociated with perioperative mortality and overall survival among patients who undergo...
View ArticleAssociation of Intake of Whole Grains and Dietary Fiber With Risk of...
This cohort study evaluates the association of increased intake of whole grains and dietary fiber with the risk of hepatocellular carcinoma.
View ArticleAspirin Use and Risk of Hepatocellular Carcinoma in Hepatitis B
Liver cancer (hepatocellular carcinoma [HCC]) incidence and mortality rates have been increasing in most countries for several decades. Currently, HCC is the second most common cause of cancer-related...
View ArticleAssociation of Daily Aspirin Therapy With Risk of Hepatocellular Carcinoma in...
This nationwide cohort study examines the risk of hepatocellular carcinoma in Taiwanese patients with chronic hepatitis B who are receiving daily aspirin therapy.
View ArticleUS Food and Drug Administration Approval of New Drugs Based on Noninferiority...
This Viewpoint highlights the drawbacks of US Food and Drug Administration approval of lenvatinib for unresectable hepatocellular cancer based on the results of a noninferiority trial.
View ArticleTreatment for Advanced Hepatocellular Carcinoma With Portal Vein Thrombosis
Portal vein tumor thrombosis (PVTT) occurs in 10% to 40% of patients with hepatocellular carcinoma (HCC) and has historically presented a major therapeutic challenge. Patients with PVTT more commonly...
View ArticleSorafenib Plus Oxaliplatin, Fluorouracil, and Leucovorin vs Sorafenib Alone
This randomized clinical trial examines whether combined sorafenib and hepatic arterial infusion of oxaliplatin, fluorouracil, and leucovorin is associated with improved survival of patients with...
View ArticleRole of Adjuvant Multimodality Therapy After Curative-Intent Resection of...
This cohort study examines whether long-term survival after curative-intent resection of ampullary adenocarcinoma may be improved by selection of patients for adjuvant therapy directed by histologic...
View ArticleAssociation of In Vitro Fertilization With Childhood Cancer in the United States
This population-based cohort study compares the incidence of childhood cancers among children conceived in vitro with incidence of childhood cancers among children conceived naturally.
View ArticleTextbook Outcome Nomograms as Multivariate Tools for Cancer Treatment...
Outcomes research in cancer surgery has traditionally been segregated into perioperative outcome and long-term survival outcome studies. In recent years, it has also become clear that perioperative...
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